ISOPROPYL ALCOHOL MSDS 2018-06-11T06:43:17+00:00



1: Chemical Product Identification

Product Name: Isopropyl alcohol
Catalogue Codes: SLI1153, SLI1579, SLI1906, SLI1246,
CAS#: 67-63-0
RTECS: NT8050000
TSCA: TSCA 8(b) inventory: Isopropyl alcohol
CI#: Not available.
Synonym: 2-Propanol
Chemical Name: isopropanol
Chemical Formula: C3-H8-O

2. Composition and Information on Ingredients 

Toxicological Data on Ingredients: Isopropyl alcohol: ORAL (LD50): Acute: 5045 mg/kg [Rat]. 3600 mg/kg [Mouse]. 6410

mg/kg [Rabbit]. DERMAL (LD50): Acute: 12800 mg/kg [Rabbit].

3: Hazards Identification

Potential Acute Health Effects:

Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, sensitizer, permeator).

Potential Chronic Health Effects:

Slightly hazardous in case of skin contact (sensitizer).

CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.



DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE].

The substance may be toxic to kidneys, liver, skin, central nervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.


4: First Aid Measures

Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15

minutes. Cold water may be used. Get medical attention.

Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used.

Serious Skin Contact: Not available.

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear.

Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention.

Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

5: Fire and Explosion Data

Flammability of the Product:                                                                       Flammable.

Auto-Ignition Temperature:                                                                        399°C (750.2°F)

Flash Points:                                                                                                       CLOSED CUP: 11.667°C (53°F) – 12.778 deg. C (55 deg. F) (TAG)

Flammable Limits:                                                                                            LOWER: 2% UPPER: 12.7%

Products of Combustion:                                                                              These products are carbon oxides (CO, CO2).

Fire Hazards in Presence of Various Substances:                                 Highly flammable in presence of open flames and sparks, of heat. Flammable in presence of oxidizing materials. Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:

Risks of explosion of the product in presence of mechanical impact: Not available. Explosive in presence of open flames and sparks, of heat.

Fire Fighting Media and Instructions:                                                       Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,

water spray or fog.

Special Remarks on Fire Hazards:                                                              Vapor may travel considerable distance to source of ignition and flash back. CAUTION: MAY BURN WITH NEAR INVISIBLE FLAME. Hydrogen peroxide sharply reduces the autoignition temperature of Isopropyl alcohol. After a delay, Isopropyl alcohol ignites on contact with dioxygenyl tetrafluoroborate, chromium trioxide, and potassium tert-butoxide. When heated to decomposition it emits acrid smoke and fumes.

Special Remarks on Explosion Hazards:                                                   Secondary alcohols are readily autoxidized in contact with oxygen or air, forming ketones and hydrogen peroxide. It can

become potentially explosive. It reacts with oxygen to form dangerously unstable peroxides which can concentrate and explode during distillation or evaporation. The presence of 2-butanone increases the reaction rate for peroxide formation. Explosive in the form of vapor when exposed to heat or flame. May form explosive mixtures with air. Isopropyl alcohol + phosgene forms isopropyl chloroformate and hydrogen chloride. In the presence of iron salts, thermal decomposition can

occur, which in some cases can become explosive. A homogeneous mixture of concentrated peroxides + isopropyl alcohol is capable of detonation by shock or heat. Barium perchlorate + isopropyl alcohol gives the highly explosive alkyl perchlorates.

It forms explosive mixtures with trinitromethane and hydrogen peroxide. It produces a violent explosive reaction when heated with aluminium isopropoxide + crotonaldehyde. Mixtures of isopropyl alcohol + nitroform are explosive.

6: Accidental Release Measures

Small Spill:

Dilute with water and mop up or absorb with an inert dry material and place in an appropriate waste disposal container.

Large Spill:

Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,

sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.


7: Handling and Storage


Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, acids.


Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possible sources of ignition (spark or flame).

8: Exposure Controls/Personal Protection

Engineering Controls:

Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapours below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection:

Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits:

TWA: 983 STEL: 1230 (mg/m3) [Australia] TWA: 200 STEL: 400 (ppm) from ACGIH (TLV) [United States] [1999] TWA: 980

STEL: 1225 (mg/m3) from NIOSH TWA: 400 STEL: 500 (ppm) from NIOSH TWA: 400 STEL: 500 (ppm) [United Kingdom

(UK)] TWA: 999 STEL: 1259 (mg/m3) [United Kingdom (UK)] TWA: 400 STEL: 500 (ppm) from OSHA (PEL) [United States]

TWA: 980 STEL: 1225 (mg/m3) from OSHA (PEL) [United States] Consult local authorities for acceptable exposure limits.

9: Physical and Chemical Properties

Physical state and appearance:                                                                  Liquid.

odour:                                                                                                                   Pleasant. odour resembling that of a mixture of ethanol and acetate

Colour:                                                                                                                 Colourless.

pH (1% soln/water):                                                                                        Not available.

Boiling Point:                                                                                                     82.5°C (180.5°F)

Melting Point:                                                                                                   -88.5°C (-127.3°F)

Critical Temperature:                                                                                     235°C (455°F)

Specific Gravity:                                                                                                0.78505 (Water = 1)

Vapor Pressure:                                                                                                4.4 kPa (@ 20°C)

Vapor Density:                                                                                                   2.07 (Air = 1)

Volatility:                                                                                                             Not available.

odour Threshold:                                                                                             22 ppm (Sittig, 1991) 700 ppm for unadapted panellists (Verschuren, 1983).

Water/Oil Dist. Coeff.:                                                                                   The product is equally soluble in oil and water; log(oil/water) = 0.1

Iconicity (in Water):                                                                                         Not available.

Dispersion Properties:                                                                                    See solubility in water, methanol, diethyl ether, n-octanol, acetone.

Solubility:                                                                                                            Easily soluble in cold water, hot water, methanol, diethyl ether, n-octanol, acetone. Insoluble in salt solution. Soluble in

benzene. Miscible with most organic solvents including alcohol, ethyl alcohol, chloroform.

10: Stability and Reactivity Data

Stability:                                                                                                               The product is stable.

Instability Temperature:                                                                               Not available.

Conditions of Instability:                                                                               Heat, Ignition sources, incompatible materials

Incompatibility with various substances:                                                Reactive with oxidizing agents, acids, alkalis.

Corrosivity:                                                                                                         Non-corrosive in presence of glass.

Special Remarks on Reactivity:                                                                   Reacts violently with hydrogen + palladium combination, nitroform, oleum, COCl2, aluminium triisopropoxide, oxidants

Incompatible with acetaldehyde, chlorine, ethylene oxide, isocyanates, acids, alkaline earth, alkali metals, caustics, amines, crotonaldehyde, phosgene, ammonia. Isopropyl alcohol reacts with metallic aluminium at high temperatures. Isopropyl alcohol attacks some plastics, rubber, and coatings. Vigorous reaction with sodium dichromate + sulfuric acid.

Special Remarks on Corrosivity:                                                                  May attack some forms of plastic, rubber and coating

Polymerization:                                                                                                 Will not occur.

11: Toxicological Information

Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.

Toxicity to Animals:

WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 3600 mg/kg [Mouse]. Acute dermal toxicity (LD50): 12800 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 16000 8 hours [Rat].

Chronic Effects on Humans:

CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.

DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. May cause

damage to the following organs: kidneys, liver, skin, central nervous system (CNS).

Other Toxic Effects on Humans:

Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, sensitizer, permeator).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans:

M a y c a u s e a d v e r s e r e p r o d u c t i v e / t e r a t o g e n i c e f f e c t s (f e r t i l i t y, f e t o x i c i t y, d e v e l o p m e n t a l abnormality (developmental toxin)) based on animal studies. Detected in maternal milk in human.

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:

Skin: May cause mild skin irritation, and sensitization. Eyes: Can cause eye irritation.

Inhalation: Breathing in small amounts of this material during normal handling is not likely to cause harmful effects. However, breathing large amounts may be harmful and may affect the respiratory system and mucous membranes (irritation), behaviour and brain (Central nervous system depression – headache, dizziness, drowsiness, stupor, incoordination, unconsciousness, coma and possible death), peripheral nerve and sensation, blood, urinary system, and liver.

Ingestion: Swallowing small amounts during normal handling is not likely to cause harmful effects. Swallowing large amounts may be harmful. Swallowing large amounts may cause gastrointestinal tract irritation with nausea, vomiting and diarrhea, abdominal pain. It also may affect the urinary system, cardiovascular system, sense organs, behaviour or central nervous system (somnolence, generally depressed activity, irritability, headache, dizziness, drowsiness), liver, and respiratory system (breathing difficulty).

Chronic Potential Health Effects: May cause defatting of the skin and dermatitis and allergic reaction. May cause adverse reproductive effects based on animal data (studies).

12: Ecological Information

Ecotoxicity: Ecotoxicity in water (LC50): 100000 mg/l 96 hours [Fathead Minnow]. 64000 mg/l 96 hours [Fathead Minnow].

BOD5 and COD: Not available.

Products of Biodegradation: Possibly hazardous short-term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation: Not available.

13: Disposal Considerations

Waste Disposal:

Waste must be disposed of in accordance with federal, state and local environmental control regulations.

14: Transport Information

DOT Classification: CLASS 3: Flammable liquid.

Identification: Isopropyl Alcohol UNNA: 1219 PG: II

Special Provisions for Transport: Not available.

15: Other Regulatory Information


Other Classifications:

WHMIS (Canada):

CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects



R11- Highly flammable. R36- Irritating to eyes. S7- Keep container tightly closed. S16- Keep away from sources of ignition

– No smoking. S24/25- Avoid contact with skin and eyes. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Protective Equipment:

Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator

when ventilation is inadequate. Splash goggles.

16: Other Information

References: Not available.

Other Special Considerations: Not available.


All information and instructions provided in this Material Safety Data Sheet in respect of the substance is given solely in terms of the provisions of the Occupational Health and Safety Act No 85 of 1993

and Regulations (“the Act”), is based on scientific and technical knowledge as at the date indicated on this MS Material Safety Data Sheet and is presented in good faith to be correct.

The information and instructions provided in this MSDS apply only to the substance in its present form and not to any formulation or mix, in which event it is the sole responsibility of the user of the substance as formulated and/or mixed to investigate and establish any danger which may arise out of its use, wherever such user may be situated.

It is the sole responsibility of the person in receipt of this Material Safety Data Sheet wherever such recipient may be situated, to ensure that the information provided is communicated to and understood by any person who may come in contact with the substance in any place and in any manner whatsoever. If such recipient produces formulations or mixes using the substance, then it is such recipient’s sole responsibility to comply with the provisions of the Act in respect of the provision of the necessary Material Safety Data Sheet, or to comply with any other applicable legislation.